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| Exposure to Both Traffic, Indoor Pollutants Puts Some Kids at Higher ... - Science Daily Posted: 26 Nov 2009 03:55 PM PST ScienceDaily (Nov. 27, 2009) New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone. Environmental health scientists at the University of Cincinnati (UC) College of Medicine have shown that children exposed to both high levels of traffic-related particles and indoor endotoxin during early life are six times more likely to experience persistent wheezing than children exposed to low levels of traffic and indoor-related pollutants. They report their findings in the Dec. 1, 2009, edition of the American Journal of Respiratory and Critical Care Medicine. This is believed to be the first study to look at the combined effects of traffic-related exposures and sampled endotoxin in children during infancy as an indicator of asthma later in life. Endotoxin, a component of bacteria thought to trigger an immune response in humans, was measured from dust samples collected prior to age 1. Based on a long-term study of children deemed at high risk for allergies later in life, UC environmental health researchers have found that 36 percent of the children studied who were exposed to high levels of both traffic-related pollution and indoor endotoxin demonstrated persistent wheezing at age 3, an early warning sign of asthma and other pulmonary conditions. Only 11 percent of children exposed to low levels of both indoor and outdoor allergens experienced wheezing; 18 percent of children exposed to low levels of indoor endotoxin and high levels of traffic-related particles experienced persistent wheezing. Endotoxin exposure alone appeared to have little effect. "There is a clear synergistic effect from co-exposure to traffic-related particles and endotoxin above and beyond what you would see with a single exposure that can be connected to persistent wheezing by age 3," explains Patrick Ryan, PhD, lead author of the study and a research assistant professor of environmental health at UC."These two exposure sources -- when simultaneously present at high levels -- appear to work together to negatively impact the health of young children with developing lungs." To conduct this study, Ryan and his colleagues utilized land-use regression modeling to calculate study participants' exposures to traffic-related particles, such as diesel exhaust. The model was designed to capture exposures at locations where the child spent more than eight hours a week between birth and age 3; for example, in their homes or at day care. "Traffic-related particles and endotoxin both seem to trigger an inflammatory response in the children monitored in this study. When put together, that effect is amplified to have a greater impact on the body's response," adds Ryan. "The earlier in life this type of exposure occurs, the more impact it may have long term. Lung development occurs in children up through age 18 or 20. Exposure earlier in life to both endotoxin and traffic will have a greater impact on developing lungs compared to adults whose lungs are already developed." This research is part of the Cincinnati Childhood Allergy and Air Pollution Study, a long-term epidemiological study examining the effects of traffic particulates on childhood respiratory health and allergy development. Funded by the National Institute of Environmental Health Sciences, the study began in 2001 and is led by Grace LeMasters, PhD, of the UC Department of Environmental Health. Study participants were chosen based on family history and residence's proximity to a major road. UC's LeMasters, David Bernstein, MD, James Lockey, MD, Tiina Reponen, PhD, Linda Levin, PhD, Sergey Grinshpun, PhD, Manuel Villareal, MD and Jeff Burkle were co-authors of the study. Gurjit Khurana Hershey, MD, PhD, of Cincinnati Children's Hospital Medical Center also participated in the research study. Story Source: Adapted from materials provided by University of Cincinnati Academic Health Center, via EurekAlert!, a service of AAAS. Note: If no author is given, the source is cited instead. This content has passed through fivefilters.org. This posting includes an audio/video/photo media file: Download Now |
| Interventions by parent mentors can effectively reduce wheezing and ... - News-Medical.Net Posted: 29 Nov 2009 10:47 PM PST UT Southwestern Medical Center researchers have found that informed adults can help families stave off complications associated with asthma. The findings, available online and in the December issue of Pediatrics, suggest that interventions by parent mentors - caregivers of asthmatic children who have received specialized topical training - can effectively reduce wheezing, asthma attacks, emergency room visits and missed adult workdays. "Childhood asthma disproportionately affects urban minority children," said Dr. Glenn Flores, professor of pediatrics and the study's lead author. "Asthma mortality among African-American children alone is almost five times higher than for white children. The goal for this study was to determine whether parent mentors would be more effective than traditional asthma care in improving asthma outcomes for minority children." Mentors in the study were parents or caregivers who got professional training from a nurse asthma specialist and a program coordinator on a variety of asthma-related topics. Training sessions and a manual were used to present examples of improving asthmatic care and focused on the importance of consistent treatment. The manual also discussed keeping asthmatic children out of hospitals, asthma medications and triggers, and cultural issues that can affect care. A total of 220 African-American and Hispanic children from Milwaukee were assigned randomly to parent mentors. The children, ranging in age from 2 to 18, were asthmatic and had been seen for complications in urban emergency departments or were hospitalized at local children's hospitals. Mentors met twice with up to 10 families with asthmatic children and telephoned parents monthly until one year after the initial emergency department visit or hospitalization. For families without telephone access, mentors conducted only home visits. Mentors also communicated regularly with the asthma nurse specialist about issues that arose with participating families. Children in the program experienced significant reductions in rapid-breathing episodes, asthma exacerbations and emergency department visits. Mentored parents or caregivers displayed greater knowledge about controlling their charger's breathing problems. "Not only did this program help the participating families, it also provided employment for those acting as parent mentors and allowed a community to address the health and needs of its children," said Dr. Flores, who holds the Judith and Charles Ginsburg Chair in Pediatrics. "The parent mentor interventions were successful social networking and show caregivers are receptive to hearing advice and instructions from their peers." Dr. Flores said additional studies and trials will need to take place to evaluate the impact of mentors on health care treatment disparities seen for asthma and other pediatric conditions. Study results also revealed that parent mentors not only are relatively inexpensive, costing an average of $60.42 per patient. The intervention group actually saved money, experiencing overall savings of $361.84 per patient for hospitalizations and $50.33 for emergency department visits. Source: UT Southwestern Medical Center This content has passed through fivefilters.org. |
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